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CHLAMYDIA

By Joseph Hazan,M.D., FACOG

 

It is the most frequently reported STD and

there are 2.5 million new cases in the US every year.

This STD is most common in persons under 25

and is transmitted during any type of sexual interaction.

Usually there is no sign of infection.

It can infect the newborn as it passes through the

birth canal.

These newborns, if untreated can have eye

or lung infections a week later.

In women it can cause heavy yellow discharge,

painful urination, pain during intercourse and spotting,

although, typically there are no symptoms.

It is detected by culture test and treated with antibiotics.

It is important to treat it before it causes PID

(Pelvic inflammatory disease) which predispose to

infertility and ectopic pregnancy,

because it may result in tubal scars.

STDs

By Joseph Hazan,M.D.,FACOG

 

STDs are sexually transmitted diseases.

The terms STIs (sexually transmitted infections) or

VD (venereal disease) are also used.

In addition to HIV/AIDS, HPV

(human papilloma virus),

LGV (lymphogranuloma venereum),

GI  9granuloma inguinale),MC (molluscum contagiosum),

PL (pubic lice), GH (genital herpes),

Lues (syphilis), Chlamydia, Gonorrhea,

Trichomonas are STIs (STDs).

Two months ago the National Center for

HIV published a study on the spread of STIs.

It is alarming that 21% of girls who claimed

to have had sex with only one partner were found

to have STI. According to this study, 25% of girls

between the ages of 14 and 19 had one or more

of the most common forms of STIs (chlamydia,

gonorrhea, genital herpes, HPV or trichomoniasis.

Among young girls who had intercourse between

age 13 and 15 it is found that 25% have an STI

by age 15. Also when treated, the reinfection

rate within six months following treatment is 25%.

As a result of STIs there are other problems

that develop, with long-term consequences.

Pelvic inflammatory disease, cervical cancer,

increased infertility, ectopic pregnancy are

some of these.

STIs also increase vulnerability to chronic or

recurrent UTIs (urinary tract infections).

Most common risk factors for STIs are 

new or multiple sex partners and inconsistent

use of barrier contraception.

Prevention, early detection, prompt and

proper treatment are very important.

Sex in Pregnancy

By Joseph Hazan,M.D., FACOG

 

During the first trimester, women may

have concerns and anxiety about

the well-being of the baby.

This can create some stress and result in

decreased interest for intercourse.

This situation can become more

pronounced as the pregnancy progresses.

During this time men can help the situation

 by taking more interest in the

pregnancy and be more reassuring and

supportive.

This is a time to improve

the relationship and foster better

communication and commitment.

The second trimester was found to

be a time when sexual activity by most

couples steadily declines and this,

in part is due to some fear and

misunderstanding.

In most uncomplicated pregnancies

there is no contraindication to intercourse.

In low-risk pregnancies intercourse does not

cause harm and regular intercourse

is not restricted.

In cases of incompetent cervix, preterm labor,

placenta previa or other complications

intercourse would need to be avoided.

In the postpartum period there are also some

changes in hormones that cause vaginal

dryness, low- estrogen state and related physical,

psychological or emotional sitiuations.

There is a decrease in female sexual desire

which could be worsened if postpartum

depression is present.

This requires treatment.

Women may feel tired frequently during

this time. It is found that one third of all

couples have issues with sex and intimacy

during and after pregnancy which can

have long-term effect.

These issues need to be

adequately explored and addressed.

Polycystic Ovary Syndrome and Heart Disease

By Joseph Hazan,M.D., FACOG

 

Polycystic Ovary Syndrome patients

frequently have increased heart disease risk.

This is related to abnormal lipid profile,

hypertension, insulin resistance and obesity.

Patients with PCOS have increased facial

hair, loss of scalp hair, elevated andogen

levels, lack of ovulation and infertility.

The normal ovulation does not occur in

PCOS patients and LH levels are elevated while

FSH levels are normal or slightly low.

Because of elevated estrogen (estradiol) levels

FSH is low (due to negative feedback).

This causes theca cells in the ovaries to proliferate

and that leads to increased androgen secretion.

Lack of periods and ovulation follows.

Metabolic syndrome and cardiometabolic

syndrome findings are also present in PCOS.

Obesity, high blood pressure and insulin

resistance are seen in these syndromes.

It is known that insulin resistance ,

hyperinsulinemia (high blood levels of insulin)

are  also related to abnormal lipid profiles.

This is because in these patients with high

insulin and androgen levels the fat cells

release the FFA’s (free fatty acids) into the

circulation. Also these FFA’s cause the liver

to make more VLDL (very low-density

lipoprotein) which lead to high

triglyceride levels.

Additionally some of these patients have

elevated CRP (C-reactive protein) which is a marker

of heart disease including myocardial infarction,

sudden cardiac death, peripheral

vascular disease and stroke.

Some patient could have no apparent

cardiovascular problem and normal lipid levels, but

high CRP (over 5 mg/L).

If the hsCRP (high sensitivity C-reactive protein) is high,

these patient may benefit from treatment to lower

these levels and reduce their cardiovascular risk.

PCOS patient can benefit from screening for

cardiovascular risk and proper intervention.

PRECOCIOUS PUBERTY

By Joseph Hazan,M.D., FACOG

 

Breast development in girls before age 8 is

considered as precocious puberty.

This is related to the first stage of puberty

which is gonadarche and is related

to the activation of estrogen production

in the ovaries as signals initiated from

the hypothalamic portion of the brain

are sent to the pituitary which then are

relayed to the ovaries in order to produce

estrogen.

Estrogen causes breasts to develop.

Additionally bone development has been

used in the criteria.

The second stage of puberty is adrenarche

which has to do with adult type

body odor and development of hair in

the arm pits and pubic area.

This is initiated by the activation of the

adrenal androgen levels as

prompted by the hypothalamus portion

of the brain signals the pituitary.

If there are seizures, headaches or visual

changes a brain related issue is

considered.

In some cases an external stimulus such

as hormone gel or cream might be

responsible. Products that contain placental

extracts, tea tree oil or lavender

oil could also be related to

precocious puberty.

The accelerated bone development is

evident in height measurements.

If height increases by more than 6 cm

a year this is usually consistent with

early puberty.

If a young girl has not started to develop

breasts but has  the characteristics of

premature adrenarche, it could be related

to insulin resistance, obesity and

high insulin levels.

Some of these girls could later develop PCOS

(polycystic ovarian syndrome).

Girls with premature adrenarche without

early onset of

breast development could be prone to

psychiatric problems.

Some of these girls who were small at birth

could en up starting their periods early

and might end up short, since the early

onset of their menses result in the early

epiphyseal maturation and therefore

short stature.

If estrogen levels are high without high

gonadotropin LH and FSH levels would

be related to an ovarian cyst or tumor.

LH and FSH levels are low with PPP

(precocious peripheral puberty)

but elevated with CPP (central precocious

puberty).

If the attainment of adult height potential

is wanted in cases of CPP the use of

GnRH analogs are considered to help delay

the onset of puberty.

REFERENCES

Carel JC, Eugster EA, Rogol A, et al.

Consensus statement on the use of gonadotropin-

releasing hormone analogs in children.

Pediatrics.2009;123(4):e752-e762.

Pregnancy with Obesity

By Joseph Hazan,M.D.,FACOG

 

It is determined that 29% of women

between the ages of 20 and 39 are obese.

Overall the rate of obesity has reached

32% and continues to increase.

BMI (body mass index) which is calculated

by taking the weight in kilograms

and dividing it by the height in m2. 

BMI 25 kg/m2 is considered overweight

and 30 kg/m2 is considered obese.

Obesity predisposes to diabetes,

hypertension,

pregnancy loss and neural

tube defect, spina bifida, heart defects,

cleft palate, cleft lip and anal atresia.

There are also difficulties with delivery,

including  cesarean section and also

with anesthesia.

Following delivery there is an increased

risk of thromboembolism.

Nutritional help and vitamin and mineral

supplementation is required.

In most cases for overweight and obese

individuals weight gain would need to

be limited to below 25 lbs during pregnancy.

BREASTFEEDING PROTECTS AGAINST SEVERAL HEALTH RISKS

By Joseph Hazan,M.D.,FACOG

 

The WHO has recommended at least 2

years of breastfeeding.

The American College of

Obstetricians and Gynecologists,

The American Academy of Family Physicians and

The American Academy of Pediatrics have

recommended exclusively breastfeeding for at least

six months and to extend this as much as

possible through the first year and thereafter.

Currently only 31.5% of infants are being

exclusively breastfed at 3 months and only

11.9% are exclusively breastfed at six months

in the US.

The public perception of formula feeding

as the norm and a misconception as to

the nutritional values of formula vs breastfeeding

contribute to these low rates.

What needs to be emphasized is

that not breastfeeding poses several

health risks to both the mother and the baby.

There are serious risks involved in

not breastfeeding and the public should

be informed.

The following is a summary of these:

1) Infection Risk

Babies who are formula fed are more

at risk to the flu, pneumonia, intestinal

viruses and bacteria, ear infections

and necrotizing enterocolitis.

Breast milk contains several immune

factors that help protect the baby.

IgA antibodies in mother’s milk help

protect the baby against respiratory and

intestinal pathogens. additionally,

oligosaccharides in breast milk help protect

the baby against H. influenzae and Strep

pneumoniae.

Glycoproteins in breast milk help protect against

E. coli, rotavirus and vibrio cholerae, while

lipids in breast milk help protect against H.

influenzae, Group B strep, G. lamblia, Strep

epidermidis, HSV 1 and RSV.

Glycosaminoglycans

in breast milk help protect against HIV.

Babies who are not breastfed have twice the risk

of ear infection.

Breast milk provides protection

against otitis media due to the oligosaccharides

and antibodies it contains.

Lipids in breast milk help protect the baby

against RSV (respiratory syncytial virus).

Babies who are exclusively breastfed fro 4 months 

are protected, while those who are not breastfed

have 3.6 times the risk of being hospitalized

during the first year of life with a lower respiratory

infection.

Babies who are not breastfed also have 1.7

times to 2.8 times higher risk for gastroenteritis.

Preterm babies who are not fed with mother’s

milk have a 2.4 times risk of necrotizing enterocolitis

which is 15% fatal.

2) Metabolic Risk

Babies who are not breastfed are at higher

risk for type 2 diabetes and obesity.

The risk is 1.6 fold.

Metabolic risk also

relates to increased incidence of hypertension

and abnormal cholesterol and triglyceride levels.

Breast milk contains adipokines that help

regulate energy intake.

3) Neurological

Babies that are not breastfed have been

observed to crawl and walk later.

Also at age 6.5 years they have verbal

IQ scores 7.5 points lower according

to one study.

4) SIDS (sudden infant death syndrome)

Risk of SIDS is shown to be 1.6 to 2.1 fold for

babies that are not breastfed.

This increased risk is found to be

attributable to factors associated with

breastfeeding rather than breastfeeding itself.

5) Other isssues

Babies that are not breastfed have higher

incidence of alkaline stools and colonization of

bowel with potentially

harmful bacteria such as C. dificile and B. fragilis.

They also have immune systems that are not

as prepared for defense.

Therefore they seem to have a higher chance

of  allergic problems and infectious diseases,

asthma, allergic skin rashes especially

atopic dermatitis.

The risk of type 1 diabetes , childhood leukemia

is also increased in babies who are not breastfed.

IMPACT ON MOTHER’S HEALTH

Mothers who have not breastfed or only

breastfed briefly have higher incidence of breast

and ovarian cancers,

Each year of breastfeeding seems to confer

4.3% reduction of risk for invasive breast cancer.

Mothers who don’t breastfeed have a tougher

time losing weight postpartum , have higher risk

of metabolic syndrome and diabetes.

The following is a useful resource on this topic:

http://www.womenshealth.gov/breastfeeding/

programs/business-case/outreach-marketing-

resources.pdf

BREASTFEEDING BENEFITS

By Joseph Hazan,M.D., FACOG

 

The evidence is now in.

 Babies who are breastfed are definitely healthier.

Mothers also benefit substantially.

Babies who are not breastfed have higher risk

of infectious illnesses, necrotizing enterocolitis,

 childhood obesity, diabetes, leukemia and SIDS

(sudden infant death syndrome).

Mother who do not breastfeed are at increased

risk of breast cancer, ovarian cancer,

obesity, diabetes, heart attack and metabolic syndrome.

In our next post we will have additional details on

this very important topic.

Endometrial Cancer

By Joseph Hazan,M.D.,FACOG

 

Endometrial Cancer is the most common

gynecological cancer.

The occurence of vaginal bleeding after

menopause is suspect.

Endometrium is the inner lining of the

uterus and in case of postmenopausal

bleeding, endometrial cancer needs to

be ruled out.

Menopause is defined as the absence

of menses for at least one year.

The average age for the “change” or

menopause is 52.

In cases of endometrial cancer irregular

and sometimes heavy bleeding

occurs around the age of menopause.

In some cases an abnormal discharge

could be present.

Endoetrial cancer is rare in younger women.

Most postmenopausal women

are alarmed if they notice the onset of

bleeding and seek medical care promptly.

Therefore this disease is usually diagnosed

fairly early and this results in a good

prognosis if the stage and grade of

cancer is relatively low.

Risk factors that are associated with

endometrial cancer are obesity, hypertension,

diabetes, polycystic ovarian disease,

lack of pregnancies, late menopause and

family history of cancer.

Birth control pill use has been found

to be associated with a lower risk for

endometrial cancer.

Diagnostic studies for endometrial cancer

include an ultrasound (pelvic ultrasonogram),

to measure endometrial thickness,

endometrial biopsy and D&C

(dilatation and curettage-

dilating the cervix and scraping the uterine

cavity to assess uterine pathology) and

hysteroscopy (to inspect the uterine

cavity and lining with a fiberoptic device).

The treatment uf endometrial cancer is

accomplished with surgery to remove the

uterus and cervix (total hysterectomy)

with tubes and ovaries (bilateral salpingo-

oophorectomy) also usually removal

of pelvic and abdominal lymph nodes

( pelvic and abdominal lymphadenectomy)

to detect and deter the spread of the disease.

WEIGHT GAIN IN PREGNANCY

By Joseph Hazan,M.D.,FACOG

 

The amount of appropriate weight gain

during pregnancy is dependent on prepregnancy

weight.

If a woman is underweight prior to pregnancy,

she may gain 28-40 lbs during pregnancy.

If she is of average weight prepregnancy,

she may gain 25-35 lbs during pregnancy.

If she is overweight, she should not gain

more than 15-25 lbs during pregnancy.

If she is obese, she should limit her

weight gain to 11-20 lbs.

It is important to remember that overweight

and obese women have higher risk of

diabetes, hypertension and cesarean birth.

Additionally, babies of overweight and obese

women are also at higher risk of larger size,

higher birth weight,  being overweight as children,

childhood diabetes and heart defect.

It is best to avoid starchy or sweet snacks,foods,

fried and fatty meals. 300 additional calories daily

should be derived from vegetable sources. 

Sugar,sodas, soft drinks should be avoided.